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The Xenopus Drm homolog, Gremlin Grem1 , was identified in a screen for genes with dorsalizing ability Hsu et al. Want Streaming Chart Updates? In zebrafish and Xenopus embryos, it is proposed that nodal-lefty forms a reaction�diffusion system to pattern embryonic tissues, as lefty is induced by nodal and diffuses faster than nodal Marjoram and Wright ; Muller et al. WDAY : However, this view is challenged by the observation that nodal may only signal over a short range, and the gradient of nodal signaling readout may rely on differential temporal regulation of nodal and lefty expression van Boxtel et al.
